【科研项目】
[1] 北京中医药大学科技处,黄连药性评价及其经典方药-半夏泻心汤配伍机制研究, 2022.09~2025
[2] 北京同仁堂股份有限公司科学研究所,牛黄上清丸治疗上焦实热证药效物质基础及作用机制研究, 2022.12~2024.12
[3] 北京同仁堂科技发展股份有限公司制药厂,京制牛黄解毒片治疗肺胃蕴热证药效物质基础及作用机制研究, 2022.12~2024.12
[4] 国家自然科学基金委员会,基于原小檗碱型生物碱构-效-性关系构建黄连、延胡索寒热药性的评价方法, 2023.1-2026.12
[5] 国家药品监督管理局,清肺排毒5号中药复方制剂研发及产业化, 2020.7-2022.6
【学术成果】
[1] Li T, Wang P, Guo W, Huang X, Tian X, Wu G, Xu B, Li F, Yan C, Liang XJ, Lei H. Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application. ACS Nano. 2019 Jun 25;13(6):6770-6781. (IF= 17.1)
[2] Cui H, Yang X, Wang Z, Li G, Li L, Huo S, Zhang B, He R, Chen K, Xu B, Wang P, Lei H. Tetrahydropalmatine triggers angiogenesis via regulation of arginine biosynthesis. Pharmacol Res. 2021 Jan;163:105242.(IF 9.3)
[3] Huang X, Liu X, Lin X, Yuan Z, Zhang Y, Wang Z, Pi W, Zhao H, Lei H, Wang P. Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine. J Nanobiotechnology. 2022 Dec 12;20(1):527. (IF 10.3)
[4] Gao S, Zheng H, Xu S, Kong J, Gao F, Wang Z, Li Y, Dai Z, Jiang X, Ding X, Lei H. Novel Natural Carrier-Free Self-Assembled Nanoparticles for Treatment of Ulcerative Colitis by Balancing Immune Microenvironment and Intestinal Barrier. Adv Healthc Mater. 2023 Sep 8:e2301826. (IF 10.0)
[5] Huang X, Wang P, Li T, Tian X, Guo W, Xu B, Huang G, Cai D, Zhou F, Zhang H, Lei H. Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus. ACS Appl Mater Interfaces. 2020 Jan 8;12(1):227-237. (IF 9.5)
【研究方向】
1.中药先导化合物发现与开发。
2.中药药性与配伍理论科学内涵及精准中药研发。
【招生专业】中药化学
【联系方式】leihaimin@126.com