【科研项目】

1.上海市科委，21Y31900200，系统性红斑狼疮重要脏器损伤早期预警和精准干预，2021/10/1~2025/9/30

2.国家自然科学基金专项项目，32141004，系统性红斑狼疮发病机制及诊疗新策略研究 ，2022/01/01~2025/12/31 

3.局级/申康发展中心，SHDC2020CR6026，系统性红斑狼疮特色队列及临床共享大数据库平台的建设，2020/12/01~2022/9/30 

4.横向课题，PNO-0104，针对原发性干燥综合征（SjS）、系统性红斑狼疮（SLE）和混合性结缔组织病（MCTD）开展的前瞻性、观察性疾病研究，2021/3/1~2022/9/30 

5.上海市科委，20MC1920300，上海市风湿与免疫疾病临床医学研究中心，2020/12/1~2023/11/30 

6.上海市卫生健康委员会，上海市临床重点专科(风湿科)建设项目2018/12/01~2023/8/31

7.国家自然科学基金重点项目，31930037，狼疮遗传相关基因组非编码区介导免疫细胞亚群特异性调控的分子机制研究，2020/1/1~2024/12/31 

8.上海市卫生局（学科建设），2017ZZ01024-02，卫计委重中之重-自身免疫性疾病临床医学中心，2020/1/1~2024/12/31 

【学术成果】

1. Xinyi Zhu#，Yutong Zhang，Zihang Yin, Zhizhong Ye，Yuting Qin，Zhaorui Cheng, Yiwei Shen, Zhihua Yin, Jianyang Ma, Yuanjia Tang, Huihua Ding, Ya   Guo* , Guojun Hou* PhD, Nan Shen*.3D chromosomal landscape reveals miR-146a dysfunctional enhancer in lupus and establishes a CRISPR-mediated approach to inhibit the IFN pathwa.Arthritis & Rheumatology.2023 Sep 20. doi: 10.1002/art.42703. Online ahead of print.
2. Ding H#, Shen Y, Hong SM, Xiang C, Shen N*.Biomarkers for systemic lupus erythematosus - a focus on organ Damage.Expert Rev Clin Immunol.2023 Sep 15. doi: 10.1080/1744666X.2023.2260098.
3. Wang Y, Lin S, Wu J, Jiang M, Lin J, Zhang Y, Ding H, Zhou H*, Shen N*, Di W*. Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions. Front Med.2023 Jun;17(3):549-561. doi: 10.1007/s11684-022-0965-7. Epub 2023 Apr 3. 
4. Zhang F, Zhang B, Ding H, Li X, Wang X, Zhang X, Liu Q, Feng Q, Han M, Chen L, Qi L, Yang D, Li X, Zhu X, Zhao Q, Qiu J, Zhu Z, Tang H, Shen N*, Wang H, Wei B.The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus. Adv Sci (Weinh).2023 Jul 19:e2207108. doi: 10.1002/advs.202207108. Epub ahead of print. PMID: 37469011.

Danting Zhang #, Fangfang Sun #, Jie Chen, Huihua Ding, Xiaodong Wang, Nan Shen *, Ting Li *, Shuang Ye *.Four trajectories of 24-hour urine protein levels in real-world lupus nephritis cohorts.RMD Open. 2023 May;9(2):e002930. doi: 10.1136/rmdopen-2022-002930.

5. Chengmei Xie, Haibo Zhou, Vicki Athanasopoulos, Qian Shen, Yaoyuan Zhang, Xiangpeng Meng, Gaetan Burgio, Todor Arsov, Adrian C Lungu, Pingjing Zhang, Yuting Qin, Jiangyang Ma, Xiaoqian Wu, Xiaoyue Jiang, Huihua Ding ，Yao Meng, Nan Shen*, Yuke He*, Carola G Vinuesa*.De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation.Arthritis Rheumatol.2023 Jun;75(6):1058-1071. doi: 10.1002/art.42416. Epub 2023 Mar 30.
6. Xiaxia Han, Shuangshuang Gu, Soon-Min Hong, Yang Jiang, Jinsong Zhang, Chao Yao, Zhihua Yin, Zhizhong Ye, Huihua Ding, Sheng Chen, Dai Dai*, Nan Shen*.Amelioration of Autoimmunity in a Lupus Mouse Model by Modulation of T-Bet-Promoted Energy Metabolism in Pathogenic Age/Autoimmune-Associated B Cells.Arthritis Rheumatol.2023 Jul;75(7):1203-1215. doi: 10.1002/art.42433. Epub 2023 May 17.
7. Shuangshuang Gu, Jinsong Zhang, Xiaxia Han, Huihua Ding, Chao Yao, Zhizhong Ye， Zhihua Yin, Guojun Hou, Yang Jiang, Jie Qian, Haibo Zhou, Qiang Guo, Sheng Chen, Dai Dai, Nan Shen*.Involvement of Transcriptional Factor Pbx1 in Peripheral B Cell Homeostasis to Constrain Lupus Autoimmunity.Arthritis Rheumatol.2023 Aug;75(8):1381-1394. doi: 10.1002/art.42487. Epub 2023 Jun 4.

Zhaorui Cheng， Guojun Hou , Nan Shen*.Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease.J Autoimmun.2023May;137:102948.doi:10.1016/j.jaut.2022.102948.

8. Guojun Hou, Tian Zhou, Ning Xu, Zhihua Yin, Xinyi Zhu, Yutong Zhang, Yange Cui, Jianyang Ma, Yuanjia Tang, Zhaorui Cheng, Yiwei Shen, Yashuo Chen, Ling-Hua Zou, Yong-Fei Wang， Zihang Yin , Ya Guo, Huihua Ding, Zhizhong Ye, Nan Shen*.Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.Arthritis Rheumatol.2023Apr;75(4):574-585.doi: 10.1002/art.42390. Epub 2023 Feb 8.
9. Xiaxia Han # , Shuangshuang Gu #, Soon-Min Hong # , Yang Jiang, Jinsong Zhang, Chao Yao, Zhihua Yin，Zhizhong Ye, Huihua Ding, Sheng Chen, Dai Dai*, Nan Shen*.Modulating T-bet-promoted energy metabolism in pathogenic age/autoimmune-associated B cells ameliorates lupus autoimmunity.Arthritis Rheumatol.2022 Dec 27.doi: 10.1002/art.42433. Online ahead of print.
10. Jiali Zhang, Qianqian Guo, Dai Dai, Jian Yu, Liting Wang, Zhihua Wu, Huihua Ding, Nan Shen*, Yourong Duan*.Rapamycin-encapsulated costimulatory ICOS/CD40L-bispecific nanoparticles restrict pathogenic helper T-B-cell interactions while in situ suppressing mTOR for lupus treatment.Biomaterials.2022  Oct;289:121766.doi:10.1016/j.biomaterials.2022.121766. Epub 2022 Aug 31.

Yao Meng, Jianyang Ma, Chao Yao, Zhizhong Ye, Huihua Ding, Can Liu , Jun Li, Guanhua Li, Yuke He, Jia Li, Zhihua Yin, Li Wu, Haibo Zhou, Nan Shen*.The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells.The Journal of Clinical Investigation.2022 Aug 15;132(16):e153619.

11. Zhou T, Zhu X, Ye Z, Wang YF, Yao C, Xu N, Zhou M, Ma J, Qin Y, Shen Y, Tang Y, Yin Z, Xu H, Zhang Y, Zang X, Ding H, Yang W, Guo Y, Harley JB, Namjou B, Kaufman KM, Kottyan LC, Weirauch MT, Hou G, Shen N*.Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery.Nat Commun.2022 Apr 6;13(1):1855. 
12. Soon-Min Hong，Wei Chen,Jiaqi Feng,Dai Dai*， and Nan Shen*.Novel Mutations in ACP5 and SAMHD1 in a Patient With Pediatric Systemic Lupus Erythematosus.Front Pediatr.2022 May 13;10:885006.
13. He Y#, Gallman AE#, Xie C, Shen Q, Ma J, Wolfreys FD, Sandy M, Arsov T, Wu X, Qin Y, Zhang P, Jiang S, Stanley M, Wu P, Tan J, Ding H, Xue H, Chen W, Xu J, Criswell LA, Nititham J, Adamski M, Kitching AR, Cook MC, Cao L, Shen N*, Cyster JG*, Vinuesa CG*.P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.J Exp Med.2022 Jan 3;219(1):e20211004.doi:10.1084/jem.20211004. Epub 2021 Dec 10.
14. Lingling Wu #, Xiaoyue Jiang #, Chaojun Qi #, Chunyan Zhang , Bo Qu *, Nan Shen *.EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice.Frontiers in immunology.2021.653989. eCollection
15. Lingling Wu#,Xiao Han#,Xiaoyue Jiang#,Huihua Ding,Chaojun Qi,Zhihua Yin,Jianwei Xiao,Le Xiong,Qiang Guo,Zhizhong Ye*,Bo Qu*,Nan Shen *.Downregulation of Renal Hsa-miR-127-3p Contributes to the Overactivation of Type I Interferon Signaling Pathway in the Kidney of Lupus Nephritis.Front Immunol.2021,12:747616.
16. Jiahuan Qin#, Xia Huang#, Naiqi Wang, Pengcheng Zhou, Hao Zhang, Zhian Chen, Kaili Liang, Dongcheng Gong, Qunxiong Zeng, Peng Niu, Anping Chen, Lin Yuan, Zhaohui Yang, Linchong Su*, Nan Shen*, Jun Deng* and Di Yu*. Supranutritional selenium suppresses ROS-induced generation of RANKL-expressing osteoclastogenic CD4+ T cells and ameliorates rheumatoid arthritis.Clinical&TranslationalImmunology.2021Sep 20;10(9):e1338.
17. Kaili Liang , Jing He , Yunbo Wei , Qunxiong Zeng , Dongcheng Gong , Jiahuan Qin , Huihua Ding , Zhian Chen , Ping Zhou , Peng Niu , Qian Chen , Chenguang Ding , Liangjing Lu , Xiao-Xiang Chen , Zhanguo Li *, Nan Shen*, Di Yu* , Jun Deng*.Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus.Clin Transl Immunology.

Guanhua Li, Lu Liu , Zhihua Yin , Zhizhong Ye, Nan Shen*.Glutamine metabolism is essential for the production of IL-17A in γδ T cells and skin inflammation.Tissue Cell.2021 Aug;71:101569.

18. Hou Guojun#; Harley Isaac T. W.#; Lu Xiaoming; Zhou Tian; Xu Ning; Yao Chao Yao; Qin Yuting; Ouyang Ye; Ma Jianyang; Zhu Xinyi Zhu; Yu Xiang; Xu Hong; Dai Dai; Ding Huihua; Yin Zhihua; Ye Zhizhong; Deng Jun; Zhou Mi; Tang Yuanjia; Namjou Bahram; Guo Ya; Weirauch Matthew T.; Kottyan Leah C.; Harley John B.; Shen Nan*.SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression.Nat Commun.2021 Jan 8;12(1):135.

Shen N*, Lipsky PE.In memoriam: Shunle Chen, MD, 1932-2021. Lupus2021 Apr;30(5):861-862.

19. Yao Meng, Jun Li, Zhizhong Ye, Zhihua Yin, Qing Sun, Zhuojun Liao, Guanhua Li, Jun Deng , Lu Liu, Yuqing Yu , Li Wu, Haibo Zhou, Nan Shen*. MicroRNA-148a facilitates inflammatory dendritic cell differentiation and autoimmunity by targeting MAFB.JCI Insight.2020 Apr 23;5(8):e133721

Jun Li, Huihua Ding, Yao Meng, Guanhua Li, Qiong Fu, Qiang Guo, Zhihua Yin, Zhizhong Ye, Haibo Zhou, Nan Shen*.Taurine metabolism aggravates the progression of lupus by promoting the function of plasmacytoid dendritic cells.Arthritis Rheumatol.2020 Dec; 72(12): 2106-2117

20. Jiali Zhang, Chuanrong Chen , Hao Fu, Jian Yu, Ying Sun, Hui Huang, Yuanjia Tang, Nan Shen*, Yourong Duan.MicroRNA-125a-Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Restoring Effector/Regulatory T Cells Balance.ACS Nano.2020 Apr 28;14(4):4414-4429
21. Huihua Ding, Cheng Lin, Jingyi Cai, Qiang Guo, Min Dai, Chandra Mohan*, Nan Shen*.Urinary activated leukocyte cell adhesion molecule as a novel biomarker of lupus nephritis histology.Arthritis research & therapy.2020 Dec;22:1-9
22. Guanhua Li, Huihua Ding, Xiang Yu, Yao Meng, Jun Li, Qiang Guo, Haibo Zhou, Nan Shen*.Spermidine suppresses inflammatory DC function by activating the FOXO3 pathway and counteracts autoimmunity.IScience.2020 Jan;23(1):100807
23. Li Wang, Rong Qiu, Zhaoyang Zhang, Zhijun Han, Chao Yao, Guojun Hou, Dai Dai, Wenfei Jin, Yuanjia Tang, Xiang Yu, Nan Shen*.The microRNA miR-22 represses Th17 cell pathogenicity by targeting PTEN-regulated pathways.Immunohorizons.2020 Jun;4(6): 308-318

Rong Qiu, Xiang Yu, Li Wang, Zhijun Han, Chao Yao, Yange Cui, Guojun Hou, Dai Dai, Wenfei Jin, Nan Shen*.Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR-21–Peli1–c-Rel Pathway Prevents Autoimmunity.The Journal of Immunology.2020 Jun;204(12): 3160-3170

24. Jing Zeng, Xinyu Meng, Ping Zhou, Zhihua Yin, Qinglian Xie, Hong Zou, Nan Shen* , Zhizhong Ye*, Yuanjia Tang*Interferon-α exacerbates neuropsychiatric phenotypes in lupus-prone mice.Arthritis Research & Therapy.2019 Sep 3;21(1):205
25. Zhuojun Liao, Zhizhong Ye, Zhixin Xue, Lingling Wu, Ye Ouyang, Chao Yao, Chaojie Cui, Ning Xu , Jianyang Ma, Guojun Hou, Jiehua Wang, Yao Meng, Zhihua Yin, Ya Liu, Jie Qian, Chunyan Zhang, Huihua Ding, Qiang Guo, Bo Qu*, Nan Shen*.Identification of Renal Long Non-coding RNA RP11-2B6.2 as a Positive Regulator of Type I Interferon Signaling Pathway in Lupus Nephritis.Frontiers in Immunology.2019 May 3;10:975
26. Chu-Xiao Liu, Xiang Li, Fang Nan, Shan Jiang, Xiang Gao, Si-Kun Guo, Wei Xue, Yange Cui, Kaige Dong, Huihua Ding, Bo Qu, Zhaocai Zhou, Nan Shen*, Li Yang*, Ling-Ling Chen*.Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.Cell.2019 May 2;177(4):865-880.e21
27. Jiehua Wang, Min Dai, Yange Cui, Guojun Hou, Jun Deng, Xin Gao, Zhuojun Liao, Ya Liu, Yao Meng, Lingling Wu, Chao Yao, Yan Wang, Jie Qian, Qiang Guo, Huihua Ding, Bo Qu, Nan Shen *.Elevated IFIT3 Contributes to Abnormal Overactive cGAS-STING Signaling in Human Systemic Lupus Erythematosus Monocytes.Arthritis Rheumatol.2018 Dec;70(12):2036-2045
28. Zhixin Xue, Chaojie Cui, Zhuojun Liao, Shiwei Xia, Pingjing Zhang, Jialin Qin, Qiang Guo, Sheng Chen, Qiong Fu, Zhihua Yin, Zhizhong Ye, Yuanjia Tang*, Nan Shen*.Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway.Front Immunol.2018 Dec 18;9:2967
29. Jiehua Wang, Min Dai, Yange Cui, Guojun Hou, Jun Deng, Xin Gao, Zhuojun Liao, Ya Liu, Yao Meng, Lingling Wu, Chao Yao, Yan Wang, Jie Qian, Qiang Guo, Huihua Ding, Bo Qu, Nan Shen*.Association of Abnormal Elevations in IFIT3 With Overactive Cyclic GMP-AMP Synthase/Stimulator of Interferon Genes Signaling in Human Systemic Lupus Erythematosus Monocytes.Arthritis & Rheumatology.2018 Dec;70(12):2036-2045
30. Zhizhang Wang, Weijie Yin, Lizhen Zhu, Jia Li, Yikun Yao, Feifei Chen, Mengmeng Sun, Jiayuan Zhang, Nan Shen*, Yan Song*， Xing Chang*.Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.Immunity.2018 Jul 17;49(1):80-92.e7.

【研究方向】沈南教授长期从事以系统统性红斑狼疮为代表的自身免疫病的发病机理、分子诊断及靶向性治疗研究。近年来通过功能基因组学、细胞及分子免疫学等多种策略在SLE关键性致病通路的研究中取得显著进展：1）率先发现I型干扰素通路异常激活是狼疮病人的主要分子表型，在此基础建立了用于评价狼疮临床亚群分类及疗效评价的新的生物标记物分析系统；2）系统性阐述Ⅰ型干扰素通路过度活化对狼疮免疫病理损伤的细胞及分子机制；3)揭示红斑狼疮Ⅰ型干扰素通路异常激活的遗传机制；4）阐明了miRNA在狼疮关键致病通路中的重要调节作用。

【招生专业】生物医学工程

【联系方式】nanshensibs@gmail.com