【科研项目】
[2] 中组部, 国家高层次人才特殊支持计划-青年拔尖人才,2023.01-2025.12;
[3] 国自然面上基金,PDGFRB 重排协同 IKZF1 突变Ph-like ALL发生及耐药中作用机制的研究,2018.1-2021.12;
[4] 国自然青年基金,组蛋白甲基化复合物 PRC2在 ETP T-ALL中作用的研究,2015.1- 2017.12;
[5] 天津市科技计划项目,细胞产品开发与临床应用,2022.1-2023.6;
[6] 中国医学科学院创新工程项目,儿童急性髓系白血病前体细胞向白血病细胞恶性转化的机制研究,2021.10-2022.10。
[7] 中国医学科学院中央级公益性科研院所基本科研业务费
,通用型造血干细胞基因编辑技术治疗儿童血液系统遗传病的研究,2021.9-2022.8;
[8]中国医学科学院中央级公益性科研院所基本科研业务费青年医学人才奖励项目,利用CRISPR/Cas9文库筛选技术和多组学测序技术探索儿童急性髓系白血病复发耐药机制,2018.10-2019.9;
[9]北京协和医学院“中央高校基本科研业务费”,AGGF1-PDGFRB在Ph-like B-ALL发生及TKI耐药中作用和机制的研究,2018.1-2018.12;
【学术成果】
[1] Clonal Evolution Dissection Reveals High MSI2 Level Promotes Chemo-resistance in T-cell Acute Lymphoblastic Leukemia. Blood. 2023 Oct 6: blood. 最后通讯(IF=23.683).
[2] Single-cell analysis highlights a population of Th17-polarized CD4+ naïve T cells showing IL6/JAK3/STAT3 activation in pediatric severe aplastic anemia, J Autoimmun, 2023 Apr:136:103026. 最后通讯(IF= 14.511).
[3] Pan-HDAC inhibitors augment IL2-induced proliferation of NK cells via the JAK2-STAT5B signaling pathway. International Immunopharmacology. 2023 Mar:116:109753.最后通讯(IF= 5.7).
[4] Elucidating Minimal Residual Disease of Pediatric B cell Acute Lymphoblastic leukemia by Single Cell Analysis.Nature Cell Biology.2022 Feb;24(2):242-252. 并列一作,排名第一(IF= 28.824);
[5] Highly efficient gene editing and single cell analysis of hematopoietic stem/progenitor cells from X-linked sideroblastic anemia patients. Signal Transduction and Targeted Therapy. 2021 Aug;14(8):101119. 最后通讯(IF= 18.187);
[6] Low absolute neutrophil count during induction therapy is an adverse prognostic factor in childhood acute lymphoblastic leukaemia.Annals of hematology. 2021 Sep; 100(9): 2269-2277. 并列通讯,排名第2(IF= 3.673);
[7] Minimal residual disease monitoring via AML1-ETO breakpoint tracing in childhood acute myeloid Leukemia. Translational Oncology. 2021 Aug;14(8):101119. 最后通讯(IF= 4.243);
[8] Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication. Cell discovery.2021 Jan 5;7(1):2. 并列一作,排名第五(IF= 10.849);
[9] Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.Blood.2020 Jan 2;135(1):41-55. 并列一作,排名第五(IF= 23.629);
[10] FLT3 pathway is a potential therapeutic target for PRC2 mutated T cell acute lymphoblastic leukemia. Blood.2018 Dec 6;132(23):2520-2524. 并列一作,排名第二;并列通讯,排名第三(IF= 23.629);
[11] PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia.Blood.2018 May 17;131(20):2256-2261. 并列一作,排名第一(IF= 23.629);
[12] Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric acute myeloid. Leukemia research leukemia. 2018 Feb:65:20-24.并列一作,排名第二(IF= 2.683);
【研究方向】干细胞与再生医学
【招生专业】生物医学工程
【联系方式】zhangyingchi@ihcams.ac.cn